Loss of Drosha underlies dopaminergic neuron toxicity in models of Parkinson’s disease

• DOI: 10.1038/s41419-018-0716-5
• Publication Date: 2018-06-07T10:25:00Z
• Authors: Ronglin Wang; Fangfang Lu; Gang Zhu; Dayun Feng; Tiejian Nie; Kai Tao; Shaosong Yang; Jie Lei; Lu Huang; Zixu Mao; Qian Yang
• Keywords: Drosha

Abstract MiRNAs, a group of powerful modulator gene expression, participate in multiple cellular processes under physiological and pathological conditions. Emerging evidence shows that Drosha, which controls the initial step canonical miRNA biogenesis, is involved modulating cell survival death models several diseases. However, role Drosha Parkinson’s disease (PD) has not been well established. Here, we show level decreases 6-OHDA-induced animal PD. 6-OHDA induced p38 MAPK-dependent phosphorylation Drosha. This triggered degradation. Enhancing protected dopaminergic (DA) neurons from toxicity both vitro vivo PD alleviated motor deficits mice. These findings reveal plays critical DA suggest stress-induced destabilization may be part process