mTOR-Myc axis drives acinar-to-dendritic cell transition and the CD4+ T cell immune response in acute pancreatitis

• DOI: 10.1038/s41419-020-2517-x
• Publication Date: 2020-06-02T10:05:50Z
• Authors: Dan Xu; Rongli Xie; Zhiwei Xu; Zhifeng Zhao; Min Ding; Wei Chen; Jun Zhang; Enqiang Mao; Erzhen Chen; Ying Chen; Kaige Yang; Tong Zhou; Jian Fei
• Keywords: Acinar cell

Abstract The inflammatory response in acute pancreatitis (AP) is associated with acinar-to-dendritic cell transition. CD4 + T-cell-mediated adaptive immune necessary for pancreatic damage. However, the effect of transition on T-cell and regulatory mechanism remain undefined. A mouse animal model AP was established by repeated intraperitoneal injection CAE. mTOR inhibitor rapamycin administered before induction. Primary acinar cells were isolated co-incubated subsets differentiated T cells. expression DC-SIGN also assessed tissues from human patients. We found expressed displayed phenotype dendritic (DCs), which promoted differentiation naive into /IFN-γ Th1 /IL-17A Th17 during AP. target gene Myc. inhibited AP-induced expression, Th1/Th17 pro-inflammatory via Acinar patients In conclusion, implicated mTOR-Myc-DC-SIGN axis, might be an effective prevention local inflammation