Knockdown of ubiquitin-like modifier-activating enzyme 2 promotes apoptosis of clear cell renal cell carcinoma cells

• DOI: 10.1038/s41419-021-04347-7
• Publication Date: 2021-11-09T17:56:48Z
• Authors: Guoxi Zhang; Junrong Zou; Jinglin Shi; Biao Qian; Kaiyang Qiu; Quanliang Liu; Tianpeng Xie; Zhihua He; Hui Xu; Yunfeng Liao; Yuting Wu; Yanmin Li; Guancheng Xiao; Yuanhu Yuan; Rihai Xiao; Gengqing Wu; Xiaofeng Zou
• Keywords: 0301 basic medicine; QH573-671; Mice, Nude; Apoptosis; Middle Aged; Article; Kidney Neoplasms; Mice; 03 medical and health sciences; Small Ubiquitin-Related Modifier Proteins; Animals; Humans; Cytology; Carcinoma, Renal Cell; Cell Proliferation

Small ubiquitin-related modifier (SUMO) proteins are involved in the development of tumors. Ubiquitin-like modifier-activating enzyme 2 (UBA2) is an important member SUMO modification system; however, its role clear cell renal carcinoma (ccRCC) unclear. Therefore, we investigated expression and function UBA2 ccRCC. Both mRNA protein levels were found to be higher ccRCC than normal tissues significantly related tumor size, Fuhrman grade, stage. knockdown inhibited growth, promoted apoptosis vitro vivo, decreased abundance a p53 mutant, c-Myc, key enzymes system. Meanwhile, overexpression had opposite effects. Overexpression mutant or c-Myc alleviated effects on proliferation apoptosis. In conclusion, targeting may have therapeutic potential against