Oxidative stress induces meiotic defects of oocytes in a mouse psoriasis model

• DOI: 10.1038/s41419-022-04948-w
• Publication Date: 2022-05-19T08:03:08Z
• Authors: ZhiQin Zhang; ShouBin Tang; YuYing Jiang; FangYuan Long; Fang He; Jian Liu; ShouYong Gu; Yan Lu; ZhiQiang Yin
• Keywords: 0301 basic medicine; QH573-671; Spindle Apparatus; Article; Mitochondria; 3. Good health; Meiosis; Mice; Oxidative Stress; 03 medical and health sciences; Pregnancy; Oocytes; Animals; Psoriasis; Female; Cytology; Melatonin

Psoriasis, an immune-mediated inflammatory disease, is associated with poor pregnancy outcomes. Emerging evidence indicates that these defects are likely attributed to compromised oocyte competence. Nevertheless, little known about the underlying mechanisms between psoriasis and quality. In this study, we construct imiquimod-induced chronic psoriasis-like mouse model review effects of on We discover oocytes from mice display spindle/chromosome disorganization, kinetochore-microtubule mis-attachment, aneuploidy. Importantly, our results show melatonin supplement in vitro vivo not only increases rate matured but also significantly attenuates oxidative stress meiotic by restoring mitochondrial function mice. Altogether, data uncover adverse symptoms oocytes, ameliorates psoriatic