Mesenchymal stem/stromal cells primed by inflammatory cytokines alleviate psoriasis-like inflammation via the TSG-6-neutrophil axis

• DOI: 10.1038/s41419-022-05445-w
• Publication Date: 2022-11-25T21:32:02Z
• Authors: Yayun Ding; Pixia Gong; Junjie Jiang; Chao Feng; Yanan Li; Xiao Su; Xiaojing Bai; Chenchang Xu; Chunxiao Liu; Jianxin Yang; Jiankai Fang; Xiaocao Ji; Yongjing Chen; Peishan Li; Lingchuan Guo; Changshun Shao; Yufang Shi
• Keywords: Proinflammatory cytokine

Abstract Psoriasis is currently an incurable skin disorder mainly driven by a chronic inflammatory response. We found that subcutaneous application of umbilical cord- derived mesenchymal stem/stromal cells (MSCs) primed IFN-γ and TNF-α, referred to as MSCs-IT, exhibited remarkable therapeutic efficacy on imiquimod (IMQ)-induced psoriasis-like inflammation in mice. Neutrophil infiltration, hallmark psoriasis, was significantly reduced after treatment with MSCs-IT. further demonstrated the effects MSCs-IT were mediated tumor necrosis factor (TNF) stimulating gene-6 (TSG-6), which greatly upregulated MSCs upon TNF-α stimulation. transduced TSG-6 siRNA lost their while recombinant applied alone could also reduce neutrophil infiltration alleviate psoriatic lesions. Furthermore, we inhibit recruitment decreasing expression CXCL1, may be related level STAT1 phosphorylation keratinocytes. Thus, blocking or has potential for human psoriasis.