The mitochondrial ATP-dependent potassium channel (mitoKATP) controls skeletal muscle structure and function

• DOI: 10.1038/s41419-024-06426-x
• Publication Date: 2024-01-17T06:02:00Z
• Authors: Giulia Di Marco; Gaia Gherardi; Agnese De Mario; Ilaria Piazza; Martina Baraldo; Andrea Mattarei; Bert Blaauw; Rosario Rizzuto; Diego De Stefani; Cristina Mammucari
• Keywords: 0301 basic medicine; 0303 health sciences; Adenosine Triphosphate; Potassium Channels; QH573-671; Cytology; Muscle, Skeletal; Article; Mitochondria, Heart; Mitochondria

Abstract MitoK ATP is a channel of the inner mitochondrial membrane that controls K + influx according to availability. Recently, genes encoding pore-forming (MITOK) and regulatory ATP-sensitive (MITOSUR) subunits mitoK were identified, allowing genetic manipulation channel. Here, we analyzed role in determining skeletal muscle structure activity. Mitok −/− muscles characterized by cristae remodeling defective oxidative metabolism, with consequent impairment exercise performance altered response damaging contractions. On other hand, constitutive MITOK overexpression triggered overt dysfunction energy default, increased protein polyubiquitination, aberrant autophagy flux, induction stress program. overexpressing therefore severely atrophic. Thus, proper modulation activity required for maintenance homeostasis function.