PRMT1 promotes Warburg effect by regulating the PKM2/PKM1 ratio in non-small cell lung cancer

• DOI: 10.1038/s41419-024-06898-x
• Publication Date: 2024-07-15T22:01:34Z
• Authors: Lu Peng; Yujiao Zhao; Jiang Tan; Jingyao Hou; Xin Jin; Dong-Xu Liu; Baiqu Huang; Jun Lu
• Keywords: Warburg Effect; PKM2

Abnormal epigenetic modifications are involved in the regulation of Warburg effect tumor cells. Protein arginine methyltransferases (PRMTs) mediate methylation and have critical functions cellular responses. PRMTs deregulated a variety cancers, but their precise roles cancer is largely unknown. Experiments from current study showed that PRMT1 was highly expressed under conditions glucose sufficiency. induced an increase PKM2/PKM1 ratio through upregulation PTBP1, turn, promoting aerobic glycolysis non-small cell lung (NSCLC). The level p53-deficient p53-mutated NSCLC remained relatively unchanged while expression reduced p53 wild-type insufficiency. Notably, activation glucose-deficient could suppress USP7 further accelerate polyubiquitin-dependent degradation PRMT1. Melatonin, hormone inhibits intake, markedly suppressed proliferation NSCLC, combination melatonin inhibitor P5091 enhanced anticancer activity NSCLC. Our collective findings support role Moreover, treatment with good efficacy, providing rationale for development PRMT1-based therapy to improve outcomes.