SOX on tumors, a comfort or a constraint?

• DOI: 10.1038/s41420-024-01834-6
• Publication Date: 2024-02-09T04:26:29Z
• Authors: Junqing Jiang; Yufei Wang; Mengyu Sun; Xiangyuan Luo; Zerui Zhang; Yijun Wang; Siwen Li; Dian Hu; Jiaqian Zhang; Zhangfan Wu; Xiaoping Chen; Bixiang Zhang; Xiao Xu; Shuai Wang; Shengjun Xu; Wenjie Huang; Limin Xia
• Keywords: Testis determining factor

The sex-determining region Y (SRY)-related high-mobility group (HMG) box (SOX) family, composed of 20 transcription factors, is a conserved family with highly homologous HMG domain. Due to their crucial role in determining cell fate, the dysregulation SOX members closely associated tumorigenesis, including tumor invasion, metastasis, proliferation, apoptosis, epithelial-mesenchymal transition, stemness and drug resistance. Despite considerable research investigate mechanisms functions confusion remains regarding aspects such as immune microenvironment (TIME) contradictory impacts exerts on tumors. This review summarizes physiological function multiple roles tumors, focus relationship between TIME, aiming propose potential cancer promising methods for treatment.