Genomic analysis of a large set of currently—and historically—important human adenovirus pathogens

• DOI: 10.1038/s41426-017-0004-y
• Publication Date: 2018-01-31T17:49:48Z
• Authors: Ashrafali M. Ismail; Tiange Cui; Kalpana Dommaraju; Gurdeep Singh; Shoaleh Dehghan; Jason Seto; Susmita Shrivastava; Nadia B. Fedorova; Neha Gupta; Timothy B. Stockwell; Ramana Madupu; Albert Heim; Adriana E. Kajon; Eric G. Romanowski; Regis P. Kowalski; Jambulingam Malathi; Kuzhanthai L. The...; Hajib Narahari Ma...; Qiwei Zhang; Leonardo J. Ferreyra; Morris S. Jones; Jaya Rajaiya; David W. Dyer; James Chodosh; Donald Seto
• Keywords: Molecular Epidemiology

Human adenoviruses (HAdVs) are uniquely important "model organisms" as they have been used to elucidate fundamental biological processes, recognized complex pathogens, and remedies for human health. As HAdVs may effect asymptomatic or mild severe symptomatic disease upon their infection of respiratory, ocular, gastrointestinal, genitourinary systems. High-resolution genomic data enhanced the understanding HAdV epidemiology, with recombination an major pathway in molecular evolution genesis emergent pathogens. To support this view actualize algorithm identifying, characterizing, typing novel HAdVs, we determined DNA sequence 95 isolates from archives containing historically pathogens collections housing currently circulating strains be sequenced. Of 85 samples that were completely sequenced, 18 recombinants within species HAdV-B D identified. Two HAdV-D genomes found contain penton base fiber genes significant divergence known types. In set, additional HAdV-D53 HAdV-D58, two genotypes recently using genomics. This supports thesis not limited "one-time" appearances prototype but importance epidemiology. These underscore significance lateral transfer reinforce potential public health impact emerging population.