Zika virus infection in human placental tissue explants is enhanced in the presence of dengue virus antibodies in-vitro

• DOI: 10.1038/s41426-018-0199-6
• Publication Date: 2018-12-01T19:36:17Z
• Authors: Kyra Hermanns; Claudia Göhner; Anne Kopp; Andre Schmidt; Waltraut M. Merz; Udo R. Markert; Sandra Junglen; Christian Drosten
• Keywords: Zika Virus

The current Zika virus (ZIKV) outbreak is associated with neurological malformations and disorders in neonates. Areas of increased incidence may overlap dengue-hyperendemic areas. ZIKV infection enhanced by antibodies against dengue (DENV) cell culture inbred mice. Sufficiently powered clinical studies or primate addressing the enhancement fetal after previous are not available. human placenta susceptible to vitro, but it unknown whether antibody-dependent occurs at placental barrier. Here we studied tissue presence DENV-immune sera. Explants from amniochorionic membrane, chorionic villi, maternal decidua were infected DENV type 1-, 2-, 4-immune sera, controls. Presence any percentage successful infections organ explants between 1.42- 2.67-fold, led a faster replication as well significantly production. No was seen yellow fever chikungunya control Pre-existing pose an risk trans-placental transmission.