Myosin efflux promotes cell elongation to coordinate chromosome segregation with cell cleavage

• DOI: 10.1038/s41467-017-00337-6
• Publication Date: 2017-08-15T10:07:27Z
• Authors: Emilie Montembault; Marie-Charlotte C...; Lou Bouit; Cedric Landmann; James Jenkins; Anna Tsankova; Clemens Cabernard; Anne Royou
• Keywords: Cleavage furrow

Chromatid segregation must be coordinated with cytokinesis to preserve genomic stability. Here we report that cells clear trailing chromatids from the cleavage site by undergoing two phases of cell elongation. The first phase relies on assembly a wide contractile ring. second requires activity pool myosin flows ring and enriches nascent daughter cortices. This efflux is novel feature its duration coupled nuclear envelope reassembly sequestration Rho-GEF Pebble. Trailing induce delay in concomitant prolonged cortical activity, thus providing forces for We propose modulation dynamics part cellular response triggered "chromatid separation checkpoint" delays and, consequently, Pebble when are present at midzone.Chromatid authors show two-step elongation demonstrate role phase.