Distinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota

• DOI: 10.1038/s41467-017-01449-9
• Publication Date: 2017-11-03T06:38:24Z
• Authors: Gregorio Iraola; Samuel C. Forster; Nitin Kumar; Philippe Lehours; Sadjia Bekal; Francisco J. Garc...; Fernando Paolicchi; Claudia Morsella; Helmut Hotzel; Po-Ren Hsueh; Ana Vidal; Simon Lévesque; Wataru Yamazaki; Claudia Balzan; Agueda Vargas; Alessandra Piccir...; Bonnie Chaban; Janet E. Hill; Laura Betancor; Luis Collado; Isabelle Truyers; Anne C. Midwinter; Hatice T. Dagi; Francis Mégraud; Lucía Calleros; Ruben Pérez; Hugo Naya; Trevor D. Lawley
• Keywords: Campylobacter fetus; Zoonosis; Human pathogen

Abstract Campylobacter fetus is a venereal pathogen of cattle and sheep, an opportunistic human pathogen. It often assumed that C. infection occurs in humans as zoonosis through food chain transmission. Here we show mammalian consists distinct evolutionary lineages, primarily associated with either or bovine hosts. We use whole-genome phylogenetics on 182 strains from 17 countries to provide evidence may have originated around 10,500 years ago “jumped” into during the livestock domestication period. detect genomes 8% healthy fecal metagenomes, where human-associated lineages are dominant type (78%). Thus, our work suggests unappreciated intestinal pathobiont likely spread by This genome-based framework will facilitate epidemiology research development improved molecular diagnostics prevention schemes for this neglected