Plasma cell survival in the absence of B cell memory

• DOI: 10.1038/s41467-017-01901-w
• Publication Date: 2017-11-20T20:56:33Z
• Authors: Erika Hammarlund; Archana Thomas; Ian J. Amanna; Lindsay A. Holden; Ov D. Slayden; Byung Park; Lina Gao; Mark K. Slifka
• Keywords: Memory B cell

Abstract Pre-existing serum antibodies play an important role in vaccine-mediated protection against infection but the underlying mechanisms of immune memory are unclear. Clinical studies indicate that antigen-specific antibody responses can be maintained for many years, leading to theories reactivation/differentiation B cells into plasma is required sustain long-term production. Here, we present a decade-long study which demonstrate site-specific survival bone marrow-derived and durable multiple virus vaccine antigens rhesus macaques years after sustained cell depletion. Moreover, BrdU + with morphology detected 10 vaccination/BrdU administration, indicating may persist prolonged period time absence division. On basis these results, long-lived represent key population responsible production serological memory.