Closed-loop stimulation of temporal cortex rescues functional networks and improves memory

• DOI: 10.1038/s41467-017-02753-0
• Publication Date: 2018-01-19T12:17:50Z
• Authors: Youssef Ezzyat; Paul A. Wanda; Deborah F. Levy; Allison Kadel; Ada Aka; Isaac Pedisich; Michael R. Sperling; Ashwini D. Sharan; Bradley C. Lega; Alexis Burks; Robert E. Gross; Cory S. Inman; Barbara C. Jobst; Mark A. Gorenstein; Kathryn A. Davis; Gregory A. Worrell; Michal T. Kucewicz; Joel M. Stein; Richard Gorniak; Sandhitsu R. Das; Daniel S. Rizzuto; Michael J. Kahana
• Keywords: Brain stimulation; Temporal cortex

Abstract Memory failures are frustrating and often the result of ineffective encoding. One approach to improving memory outcomes is through direct modulation brain activity with electrical stimulation. Previous efforts, however, have reported inconsistent effects when using open-loop stimulation target hippocampus medial temporal lobes. Here we use a closed-loop system monitor decode neural from recordings in humans. We apply targeted lateral cortex report that this rescues periods poor This also improves later recall, revealing reliable for enhancement. Taken together, our results suggest such systems may provide therapeutic treating dysfunction.