CD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells

• DOI: 10.1038/s41467-018-02911-y
• Publication Date: 2018-02-09T10:36:14Z
• Authors: K. Oleinika; E. C. Rosser; D. E. Matei; K. Nistala; A. Bosma; I. Drozdov; C. Mauri
• Keywords: Regulatory B cells; CD1D; Adoptive Cell Transfer; Cytokine Storm

Regulatory B cells (Breg) express high levels of CD1d that presents lipid antigens to invariant natural killer T (iNKT) cells. The function in Breg biology and iNKT cell activity during inflammation remains unclear. Here we show, using chimeric mice, depletion adoptive transfer, CD1d-lipid presentation by Bregs induces secrete interferon (IFN)-γ contribute, partially, the downregulation helper (Th)1 Th17-adaptive immune responses ameliorate experimental arthritis. Mice lacking CD1d-expressing develop exacerbated disease compared wild-type fail respond treatment with prototypical agonist α-galactosylceramide. absence alters activation disruption metabolism regulation cytokine responses. Thus, identify a mechanism which restrain excessive via presentation.