Compression force sensing regulates integrin αIIbβ3 adhesive function on diabetic platelets

• DOI: 10.1038/s41467-018-03430-6
• Publication Date: 2018-03-08T22:05:04Z
• Authors: Lining Ju; James D. McFadyen; Saheb Al-Daher; Imala Alwis; Yunfeng Chen; Lotte L. Tønnesen; Sophie Maiocchi; Brianna Coulter; Anna C. Calkin; Eric I. Felner; Neale Cohen; Yuping Yuan; Simone M. Schoenw...; Mark E. Cooper; Cheng Zhu; Shaun P. Jackson
• Keywords: Platelet adhesiveness

Diabetes is associated with an exaggerated platelet thrombotic response at sites of vascular injury. Biomechanical forces regulate activation, although the impact diabetes on this process remains ill-defined. Using a biomembrane force probe (BFP), we demonstrate that compressive activates integrin α