ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration
Male
Nicotiana
Science
Primary Cell Culture
610
Retinal Pigment Epithelium
Complex Mixtures
Article
Histone Deacetylases
Epigenesis, Genetic
Macular Degeneration
03 medical and health sciences
Smoke
Humans
Eye Proteins
Aged
Aged, 80 and over
0303 health sciences
Q
High-Throughput Nucleotide Sequencing
Epithelial Cells
Chromatin
Case-Control Studies
Female
Genome-Wide Association Study
Transcription Factors
DOI:
10.1038/s41467-018-03856-y
Publication Date:
2018-04-04T14:29:47Z
AUTHORS (15)
ABSTRACT
Age-related macular degeneration (AMD) is a significant cause of vision loss in the elderly. The extent to which epigenetic changes regulate AMD progression unclear. Here we globally profile chromatin accessibility using ATAC-Seq retina and retinal pigmented epithelium (RPE) from control patients. Global decreases occur RPE with early AMD, advanced disease, suggesting that dysfunction drives disease onset. Footprints photoreceptor RPE-specific transcription factors are enriched differentially accessible regions (DARs). Genes associated DARs show altered expression AMD. Cigarette smoke treatment cells recapitulates seen providing an link between known risk factor for pathology. Finally, overexpression HDAC11 partially responsible observed reduction accessibility, may be potential new therapeutic target
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CITATIONS (147)
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