The human Vδ2+ T-cell compartment comprises distinct innate-like Vγ9+ and adaptive Vγ9- subsets

• DOI: 10.1038/s41467-018-04076-0
• Publication Date: 2018-04-26T08:48:04Z
• Authors: Martin S. Davey; Carrie R. Willcox; Stuart Hunter; Sofya A. Kasatskaya; Ester B. M. Remme...; Mahboob Salim; Fiyaz Mohammed; Frederike J. Beme...; Dmitriy M. Chudakov; Ye H. Oo; Benjamin E. Willcox
• Keywords: Immunosurveillance; Compartment (ship)

Abstract Vδ2 + T cells form the predominant human γδ T-cell population in peripheral blood and mediate receptor (TCR)-dependent anti-microbial anti-tumour immunity. Here we show that compartment comprises both innate-like adaptive subsets. Vγ9 display semi-invariant TCR repertoires, featuring public sequences equivalent cord adult blood. By contrast, also identify a separate, − subset typically has CD27 hi CCR7 CD28 IL-7Rα naive-like phenotype diverse repertoire, however response to viral infection, undergoes clonal expansion differentiation lo CD45RA CX 3 CR1 granzymeA/B effector phenotype. Consistent with function solid tissue immunosurveillance, detect intrahepatic dominant expansions an These findings redefine subsets by delineating into (Vγ9 ) subsets, which have distinct functions microbial immunosurveillance.