Ketamine reduces aversion in rodent pain models by suppressing hyperactivity of the anterior cingulate cortex

• DOI: 10.1038/s41467-018-06295-x
• Publication Date: 2018-09-10T09:36:46Z
• Authors: Haocheng Zhou; Qiaosheng Zhang; Erik Martinez; Jahrane Dale; Sile Hu; Eric Zhang; Kevin Liu; Dong Huang; Guang Yang; Zhe Chen; Jing Wang
• Keywords: Cingulate cortex

Abstract Chronic pain is known to induce an amplified aversive reaction peripheral nociceptive inputs. This enhanced affective response constitutes a key pathologic feature of chronic syndromes such as fibromyalgia. However, the neural mechanisms that underlie this important aspect processing remain poorly understood, hindering development treatments. Here, we show single dose ketamine can produce persistent reduction in noxious stimuli rodent models, long after termination its anti-nociceptive effects. Furthermore, demonstrated anti-aversive property mediated by prolonged suppression hyperactivity neurons anterior cingulate cortex (ACC), brain region well regulate affect. Therefore, our results indicate it feasible dissociate from sensory component pain, and demonstrate potential for low-dose be therapy syndromes.