Cancer cells with trapped nuclei cut their way through the extracellular matrix

• DOI: 10.1038/s41467-018-06351-6
• Publication Date: 2018-09-21T13:43:42Z
• Authors: Emmanuel Dornier; Jim C. Norman
• Keywords: Matrix (chemical analysis); MMP1

When an invading cancer cell attempts to pass through a hole in the extracellular matrix (ECM) which is too small for its nucleus, this generates physical tension. This tension sensed by nucleus–centrosome connection that activates trafficking of endosomal vesicles containing metalloprotease, MT1-MMP1 site constraint. Recent evidence shows how focussed ECM degradation relieves constraint and allows cells continue invading.