Maternal gut and breast milk microbiota affect infant gut antibiotic resistome and mobile genetic elements

Resistome
DOI: 10.1038/s41467-018-06393-w Publication Date: 2018-09-18T16:27:05Z
ABSTRACT
Abstract The infant gut microbiota has a high abundance of antibiotic resistance genes (ARGs) compared to adults, even in the absence exposure. Here we study potential sources ARGs by performing metagenomic sequencing breast milk, as well and maternal microbiomes. We find that fecal ARG mobile genetic element (MGE) profiles infants are more similar those their own mothers than unrelated mothers. MGEs mothers’ milk also shared with infants. Termination breastfeeding intrapartum prophylaxis mothers, which have affect microbial community composition, associated higher abundances specific ARGs, composition is largely shaped bacterial phylogeny gut. Our results suggest inherit legacy past consumption via transmission genes, but still strongly impacts overall load.
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