Immune-suppression by OsHV-1 viral infection causes fatal bacteraemia in Pacific oysters

• DOI: 10.1038/s41467-018-06659-3
• Publication Date: 2018-10-05T11:15:37Z
• Authors: Julien de Lorgeril; Aude Lucasson; Bruno Petton; Eve Toulza; Caroline Montagnani; Camille Clerissi; Jeremie Vidal-Dupiol; Cristian Chaparro; Richard Galinier; Jean-Michel Escoubas; Philippe Haffner; Lionel Dégremont; Guillaume M. Char...; Maxime Lafont; Abigaïl Delort; Agnès Vergnes; Marlène Chiarello; Nicole Faury; Tristan Rubio; Marc A. Leroy; Adeline Pérignon; Denis Régler; Benjamin Morga; Marianne Alunno-B...; Pierre Boudry; Frédérique Le Roux; Delphine Destoumi...; Yannick Gueguen; Guillaume Mitta
• Keywords: Pacific oyster; DECIPHER

Infectious diseases are mostly explored using reductionist approaches despite repeated evidence showing them to be strongly influenced by numerous interacting host and environmental factors. Many with a complex aetiology therefore remain misunderstood. By developing holistic approach tackle the complexity of interactions, we decipher intra-host interactions underlying Pacific oyster mortality syndrome affecting juveniles Crassostrea gigas, main species exploited worldwide. Using experimental infections reproducing natural route infection combining thorough molecular analyses families contrasted susceptibilities, demonstrate that disease is caused multiple an initial necessary step haemocytes Ostreid herpesvirus OsHV-1 µVar. Viral replication leads entering immune-compromised state, evolving towards subsequent bacteraemia opportunistic bacteria. We propose application our integrative other multifactorial affect non-model