The transcription factor Foxp1 preserves integrity of an active Foxp3 locus in extrathymic Treg cells

• DOI: 10.1038/s41467-018-07018-y
• Publication Date: 2018-10-22T12:01:03Z
• Authors: Sayantani Ghosh; Sinchita Roy-Chow...; Keunsoo Kang; Sin-Hyeog Im; Dipayan Rudra
• Keywords: Forkhead Transcription Factors

Abstract Regulatory T (Treg) cells, which are broadly classified as thymically derived (tTreg) or extrathymically induced (iTreg), suppress immune responses and display stringent dependence to the transcription factor Foxp3. However precise understanding of molecular events that promote preserve Foxp3 expression in Treg cells is still evolving. Here we show Foxp1, a forkhead sibling family member Foxp3, essential for sustaining optimal specifically iTreg cells. Deletion Foxp1 renders gradually lose resulting dramatically reduced Nrp1 − Helios compartment well augmented intestinal inflammation aged mice. Our finding underscores mechanistic module evolutionarily related factors establish program ensure efficient homeostasis. Furthermore, it provides novel target can be potentially modulated exclusively reinforce stability keeping their thymic counterpart unperturbed.