A time-resolved multi-omic atlas of the developing mouse stomach

• DOI: 10.1038/s41467-018-07463-9
• Publication Date: 2018-11-15T15:47:27Z
• Authors: Xianju Li; Chunchao Zhang; Tongqing Gong; Xiaotian Ni; Jin’e Li; Dongdong Zhan; Mingwei Liu; Lei Song; Chen Ding; Jianming Xu; Bei Zhen; Yi Wang; Jun Qin
• Keywords: Proteome; Human Protein Atlas; Stomach cancer

The mammalian stomach is structurally highly diverse and its organ functionality critically depends on a normal embryonic development. Although there have been several studies the morphological changes during development, system-wide analysis of underlying molecular lacking. Here, we present comprehensive, temporal proteome transcriptome atlas mouse at multiple developmental stages. Quantitative 12,108 gene products allows identifying three distinct phases based in proteins RNAs gain functions longitudinal time scale. indicates functionally important isoforms relevant to development identifies unannotated novel splicing junction transcripts that validate peptide level. Importantly, many differentially expressed are also significantly overexpressed diffuse-type gastric cancer. Overall, our study provides resource understand connection cancer tumorigenesis.