A clinically translatable hyperspectral endoscopy (HySE) system for imaging the gastrointestinal tract

• DOI: 10.1038/s41467-019-09484-4
• Publication Date: 2019-04-23T10:04:03Z
• Authors: Jonghee Yoon; James Joseph; Dale J. Waterhouse; A. Siri Luthman; George S. D. Gordon; Massimiliano di P...; Wladyslaw Janusze...; Rebecca C. Fitzge...; Sarah E. Bohndiek
• Keywords: Endoscope; Ex vivo

Abstract Hyperspectral imaging (HSI) enables visualisation of morphological and biochemical information, which could improve disease diagnostic accuracy. Unfortunately, the wide range image distortions that arise during flexible endoscopy in clinic have made integration HSI challenging. To address this challenge, we demonstrate a hyperspectral endoscope (HySE) simultaneously records intrinsically co-registered standard-of-care white light images, allows to be compensated computationally an accurate data cube reconstructed as moves lumen. Evaluation HySE performance shows excellent spatial, spectral temporal resolution high colour fidelity. Application enables: quantification blood oxygenation levels tissue mimicking phantoms; differentiation profiles from normal pathological ex vivo human tissues; recording under freehand motion within intact pig oesophagus model. therefore potential for enabling clinical endoscopy.