Comprehensive genomic and immunological characterization of Chinese non-small cell lung cancer patients

• DOI: 10.1038/s41467-019-09762-1
• Publication Date: 2019-04-16T10:03:21Z
• Authors: Xu-Chao Zhang; Jun Wang; Guo-Guang Shao; Qun Wang; Xiaotao Qu; Bo Wang; Christopher Moy; Yue Fan; Zayed Albertyn; Xiayu Huang; Jingyu Zhang; Yang Qiu; Suso Platero; Matthew V. Lorenzi; Enrique Zudaire; Jennifer Yang; Ying Cheng; Lin Xu; Yi-Long Wu
• Keywords: Male; Cancer Immunoediting; Cancer Research; Lung Neoplasms; Advancements in Lung Cancer Research; Datasets as Topic; Carcinoma, Non-Small-Cell Lung; Pathology; Wnt Signaling Pathway; Cancer; Antigen Presentation; 0303 health sciences; Q; Intratumor Heterogeneity; Life Sciences; Genomics; Middle Aged; 3. Good health; ErbB Receptors; Oncology; Carcinoma, Squamous Cell; Medicine; Biomarkers for Immunotherapy; Female; Lung cancer; Pulmonary and Respiratory Medicine; Science; Immunology; Adenocarcinoma of Lung; Cancer research; Adenocarcinoma; Article; Cancer Immunotherapy; Proto-Oncogene Proteins p21(ras); 03 medical and health sciences; Lymphocytes, Tumor-Infiltrating; Cancer Genomics; Asian People; Biochemistry, Genetics and Molecular Biology; Health Sciences; KRAS; Genetics; Humans; Biomarker Analysis; Biology; Aged; FOS: Clinical medicine; CD8; Colorectal cancer; Genomic Landscape of Cancer and Mutational Signatures; Immune system; FOS: Biological sciences; Mutation; Cell; T-Lymphocytes, Cytotoxic

Abstract Deep understanding of the genomic and immunological differences between Chinese Western lung cancer patients is great importance for target therapy selection development patients. Here we report an extensive molecular immune profiling study 245 with non-small cell cancer. Tumor-infiltrating lymphocyte estimated using signatures found to be significantly higher in adenocarcinoma (ADC, 72.5%) compared squamous carcinoma (SQCC, 54.4%). The correlation alterations reveals that low infiltration was associated EGFR mutations ADC samples, PI3K and/or WNT pathway activation SQCC. While KRAS are T samples. SQCC high antigen presentation machinery cytotoxic signature scores have a prolonged overall survival time.