Regeneration of severely damaged lungs using an interventional cross-circulation platform

• DOI: 10.1038/s41467-019-09908-1
• Publication Date: 2019-05-09T12:21:49Z
• Authors: Brandon A. Guenthart; John D. O’Neill; Jinho Kim; Dawn Queen; Scott Chicotka; Kenmond Fung; Michael Simpson; Rachel Donocoff; Michael Salna; Charles C. Marboe; Katherine Cunningham; Susan P. Halligan; Holly M. Wobma; Ahmed E. Hozain; Alexander Romanov; Gordana Vunjak-No...; Matthew Bacchetta
• Keywords: Circulation (fluid dynamics)

The number of available donor organs limits lung transplantation, the only lifesaving therapy for increasing population patients with end-stage disease. A prevalent etiology injury that renders lungs unacceptable transplantation is gastric aspiration, a deleterious insult to pulmonary epithelium. Currently, severely damaged cannot be salvaged existing devices or methods. Here we report regeneration repaired meet criteria by utilizing an interventional cross-circulation platform in clinically relevant swine model aspiration injury. Enabled living swine, prolonged extracorporeal support results significant improvements function, cellular regeneration, and development diagnostic tools non-invasive organ evaluation repair. We therefore propose use could enable recovery otherwise unsalvageable thus expand pool.