An ancestral NB-LRR with duplicated 3′UTRs confers stripe rust resistance in wheat and barley

• DOI: 10.1038/s41467-019-11872-9
• Publication Date: 2019-09-06T13:22:00Z
• Authors: Chaozhong Zhang; Lin Huang; Huifei Zhang; Qunqun Hao; Bo Lyu; Meinan Wang; Lynn Epstein; Miao Liu; Chunlan Kou; Juan Qi; Fengjuan Chen; Mengkai Li; Ge Gao; Fei Ni; Lianquan Zhang; Ming Hao; Jirui Wang; Xianming Chen; Ming-Cheng Luo; Youliang Zheng; Jiajie Wu; Dengcai Liu; Daolin Fu
• Keywords: Aegilops tauschii; Triticeae; Common wheat; Aegilops

Abstract Wheat stripe rust, caused by Puccinia striiformis f. sp. tritici ( Pst ), is a global threat to wheat production. Aegilops tauschii , one of the progenitors, carries YrAS2388 locus for resistance on chromosome 4DS. We reveal that encodes typical nucleotide oligomerization domain-like receptor (NLR). The -resistant allele YrAS2388R has duplicated 3’ untranslated regions and characterized alternative splicing in nucleotide-binding domain. Mutation disrupts its synthetic hexaploid wheat; transgenic plants with show eleven races common race P . hordei barley. occurs only Ae. -derived it absent 100% n = 461) lines tested. cloning will facilitate breeding rust other Triticeae species.