A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus

• DOI: 10.1038/s41467-019-13404-x
• Publication Date: 2019-11-27T11:02:46Z
• Authors: A. Marieke Oudelaar; Caroline L. Harrold; Lars L. P. Hanssen; Jelena M. Telenius; Douglas R. Higgs; Jim R. Hughes
• Keywords: ChIA-PET; Locus control region

Specific communication between gene promoters and enhancers is critical for accurate regulation of expression. However, it remains unclear how specific interactions multiple regulatory elements contained within a single chromatin domain are coordinated. Recent technological advances which can detect multi-way at alleles provide insights into cooperate or compete transcriptional activation. Here, we use such an approach to investigate the α-globin distributed in mouse model extended include several additional genes. Our data show that do not form mutually exclusive with enhancers, but all interact simultaneously complex. These findings suggest structurally hub structure, consistent recent models activation occurring non-membrane bound nuclear compartments.