Maternal vaccination and protective immunity against Zika virus vertical transmission

• DOI: 10.1038/s41467-019-13589-1
• Publication Date: 2019-12-12T15:10:09Z
• Authors: Chao Shan; Xuping Xie; Huanle Luo; Antonio E. Muruato; Yang Liu; Maki Wakamiya; Jun-Ho La; Jin Mo Chung; Scott C. Weaver; Tian Wang; Pei-Yong Shi
• Keywords: Zika Virus

Abstract An important goal of the Zika virus (ZIKV) vaccine is to prevent a congenital syndrome in fetuses pregnant women, but studies directly evaluating maternal vaccination for ZIKV are lacking. Here we report using live-attenuated (3ʹUTR-∆10-LAV) mouse model. Maternal immunization with 3ʹUTR-∆10-LAV does not cause any adverse effects on pregnancy, fetal development, or offspring behavior. One fully protects dams against infection and utero transmission. Although neutralizing antibody alone sufficient transmission, higher titer required protect mice transmission than that non-pregnant viral infection. The immunized transfer antibodies pups, which neonates Notably, pregnancy weakens T cell response vaccination. Our results suggest that, besides vaccinating individuals, may also be considered