Implementing digital computing with DNA-based switching circuits

• DOI: 10.1038/s41467-019-13980-y
• Publication Date: 2020-01-08T11:03:00Z
• Authors: Fei Wang; Hui Lv; Qian Li; Jiang Li; Xueli Zhang; Jiye Shi; Lihua Wang; Chunhai Fan
• Keywords: DNA Computing

Abstract DNA strand displacement reactions (SDRs) provide a set of intelligent toolboxes for developing molecular computation. Whereas SDR-based logic gate circuits have achieved high level complexity, the scale-up practical achievable computational tasks remains hurdle. Switching that were originally proposed by Shannon in 1938 and nowadays widely used telecommunication represent an alternative efficient means to realize fast-speed high-bandwidth communication. Here we develop switching (DSCs) implementing digital computing. Using routing strategy on programmable switch canvas, show arbitrary Boolean functions can be represented DSCs implemented with switches computing speed. We further demonstrate implementation full-adder square-rooting using DSCs, which only uses down 1/4 strands as compared dual-rail expression-based design. expect design paradigm computation biomolecules.