Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease

• DOI: 10.1038/s41467-019-14159-1
• Publication Date: 2020-01-17T11:03:05Z
• Authors: Nicolai Franzmeier; Julia Neitzel; Anna Rubinski; Ruben Smith; Olof Strandberg; Rik Ossenkoppele; Oskar Hansson; Michael Ewers; ; Michael Weiner; Paul Aisen; Ronald Petersen; Clifford R. Jack; William Jagust; John Q. Trojanowki; Arthur W. Toga; Laurel Beckett; Robert C. Green; Andrew J. Saykin; John Morris; Leslie M. Shaw; Enchi Liu; Tom Montine; Ronald G. Thomas; Michael Donohue; Sarah Walter; Devon Gessert; Tamie Sather; Gus Jiminez; Danielle Harvey; Michael Donohue; Matthew Bernstein; Nick Fox; Paul Thompson; Norbert Schuff; Charles DeCArli; Bret Borowski; Jeff Gunter; Matt Senjem; Prashanthi Vemuri; David Jones; Kejal Kantarci; Chad Ward; Robert A. Koeppe; Norm Foster; Eric M. Reiman; Kewei Chen; Chet Mathis; Susan Landau; Nigel J. Cairns; Erin Householder; Lisa Taylor Reinwald; Virginia Lee; Magdalena Korecka; Michal Figurski; Karen Crawford; Scott Neu; Tatiana M. Foroud; Steven Potkin; Li Shen; Faber Kelley; Sungeun Kim; Kwangsik Nho; Zaven Kachaturian; Richard Frank; Peter J. Snyder; Susan Molchan; Jeffrey Kaye; Joseph Quinn; Betty Lind; Raina Carter; Sara Dolen; Lon S. Schneider; Sonia Pawluczyk; Mauricio Beccera; Liberty Teodoro; Bryan M. Spann; James Brewer; Helen Vanderswag; Adam Fleisher; Judith L. Heidebrink; Joanne L. Lord; Ronald Petersen; Sara S. Mason; Colleen S. Albers; David Knopman; Kris Johnson; Rachelle S. Doody; Javier Villanueva...; Munir Chowdhury; Susan Rountree; Mimi Dang; Yaakov Stern; Lawrence S. Honig; Karen L. Bell; Beau Ances; John C. Morris; Maria Carroll; Sue Leon; Erin Householder; Mark A. Mintun; Stacy Schneider; Angela OliverNG; Randall Griffith; David Clark; David Geldmacher; John Brockington; Erik Roberson; Hillel Grossman; Effie Mitsis; Leyla deToledo-Mo...; Raj C. Shah; Ranjan Duara; Daniel Varon; Maria T. Greig; Peggy Roberts; Marilyn Albert; Chiadi Onyike; Daniel D’Agostino; Stephanie Kielb; James E. Galvin; Dana M. Pogorelec; Brittany Cerbone; Christina A. Michel; Henry Rusinek; Mony J de Leon; Lidia Glodzik; Susan De Santi; P. Murali Doraiswamy; Jeffrey R. Petrella; Terence Z. Wong; Steven E. Arnold; Jason H. Karlawish; David Wolk; Charles D. Smith; Greg Jicha; Peter Hardy; Partha Sinha; Elizabeth Oates; Gary Conrad; Oscar L. Lopez; MaryAnn Oakley; Donna M. Simpson; Anton P. Porstein...; Bonnie S. Goldstein; Kim Martin; Kelly M. Makino; M. Saleem Ismail; Connie Brand; Ruth A. Mulnard; Gaby Thai; Catherine Mc Adam...; Kyle Womack; Dana Mathews; Mary Quiceno; Ramon Diaz Arrastia; Richard King; Myron Weiner; Kristen Martin Cook; Michael DeVous; Allan I. Levey; James J. Lah; Janet S. Cellar; Jeffrey M. Burns; Heather S. Anderson; Russell H. Swerdlow; Liana Apostolova; Kathleen Tingus; Ellen Woo; Daniel H. S. Silv...; Po H. Lu; George Bartzokis; Neill R Graff Rad...; Francine ParfittH; Tracy Kendall; Heather Johnson; Martin R. Farlow; Ann Marie Hake; Brandy R. Matthews; Scott Herring; Cynthia Hunt; Christopher H. va...; Richard E. Carson; Martha G. MacAvoy; Howard Chertkow; Howard Bergman; Chris Hosein; Sandra Black; Bojana Stefanovic; Curtis Caldwell; Ging Yuek Robin H...; Howard Feldman; Benita Mudge; Michele Assaly Past; Andrew Kertesz; John Rogers; Dick Trost; Charles Bernick; Donna Munic; Diana Kerwin; Marek Marsel Mesulam; Kristine Lipowski; Chuang Kuo Wu; Nancy Johnson; Carl Sadowsky; Walter Martinez; Teresa Villena; Raymond Scott Turner; Kathleen Johnson; Brigid Reynolds; Reisa A. Sperling; Keith A. Johnson; Gad Marshall; Meghan Frey; Jerome Yesavage; Joy L. Taylor; Barton Lane; Allyson Rosen; Jared Tinklenberg; Marwan N. Sabbagh; Christine M. Belden; Sandra A. Jacobson; Sherye A. Sirrel; Neil Kowall; Ronald Killiany; Andrew E. Budson; Alexander Norbash; Patricia Lynn Joh...; Thomas O. Obisesan; Saba Wolday; Joanne Allard; Alan Lerner; Paula Ogrocki; Leon Hudson; Evan Fletcher; Owen Carmichael; John Olichney; Charles DeCarli; Smita Kittur; Michael Borrie; T Y Lee; Rob Bartha; Sterling Johnson; Sanjay Asthana; Cynthia M. Carlsson; Steven G. Potkin; Adrian Preda; Dana Nguyen; Pierre Tariot; Adam Fleisher; Stephanie Reeder; Vernice Bates; Horacio Capote; Michelle Rainka; Douglas W. Scharre; Maria Kataki; Anahita Adeli; Earl A. Zimmerman; Dzintra Celmins; Alice D. Brown; Godfrey D. Pearlson; Karen Blank; Karen Anderson; Robert B. Santulli; Tamar J. Kitzmiller; Eben S. Schwartz; Kaycee M. SinkS; Jeff D. Williamson; Pradeep Garg; Franklin Watkins; Brian R. Ott; Henry Querfurth; Geoffrey Tremont; Stephen Salloway; Paul Malloy; Stephen Correia; Howard J. Rosen; Bruce L. Miller; Jacobo Mintzer; Kenneth Spicer; David Bachman; Elizabether Finger; Stephen Pasternak; Irina Rachinsky; John Rogers; Andrew Kertesz; Dick Drost; Nunzio Pomara; Raymundo Hernando; Antero Sarrael; Susan K. Schultz; Laura L. Boles Ponto; Hyungsub Shim; Karen Elizabeth S...; Norman Relkin; Gloria Chaing; Lisa Raudin; Amanda Smith; Kristin Fargher; Balebail Ashok Raj
• Keywords: Male; Aging; Amyloid; Science; Biological Psychology; 610; tau Proteins; Neurodegenerative; Alzheimer's Disease; Article; 03 medical and health sciences; 0302 clinical medicine; Clinical Research; Alzheimer Disease; Acquired Cognitive Impairment; 80 and over; Psychology; 2.1 Biological and endogenous factors; Humans; Cognitive Dysfunction; Aged; Aged, 80 and over; Q; Neurosciences; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Brain; Alzheimer’s Disease Neuroimaging Initiative; Biological Sciences; Magnetic Resonance Imaging; Brain Disorders; Cross-Sectional Studies; Positron-Emission Tomography; Neurological; Biomedical Imaging; Dementia; Female; Biochemistry and Cell Biology; Biomarkers

Abstract In Alzheimer’s diseases (AD), tau pathology is strongly associated with cognitive decline. Preclinical evidence suggests that spreads across connected neurons in an activity-dependent manner. Supporting this, cross-sectional AD studies show deposition patterns resemble functional brain networks. However, whether higher connectivity rates of accumulation unclear. Here, we combine resting-state fMRI longitudinal tau-PET two independent samples including 53 (ADNI) and 41 (BioFINDER) amyloid-biomarker defined subjects 28 vs. 16 amyloid-negative healthy controls. both samples, faster than Second, AD, fMRI-assessed between 400 regions interest (ROIs) correlated corresponding ROIs. Third, a model baseline future accumulation. Together, spread supporting the view transneuronal propagation.