Angiotensin II induces coordinated calcium bursts in aldosterone-producing adrenal rosettes

• DOI: 10.1038/s41467-020-15408-4
• Publication Date: 2020-04-03T10:06:32Z
• Authors: Nick A. Guagliardo; Peter M. Klein; Christina A. Ganc...; Adam Lu; Sining Leng; Rany R. Makarem; Chelsea Cho; Craig G. Rusin; David T. Breault; Paula Q. Barrett; Mark P. Beenhakker
• Keywords: Rosette (schizont appearance)

Abstract Aldosterone-producing zona glomerulosa (zG) cells of the adrenal gland arrange in distinct multi-cellular rosettes that provide a structural framework for cortex morphogenesis and plasticity. Whether this cyto-architecture also plays functional roles signaling remains unexplored. To determine if structure informs function, we generated mice with zG-specific expression GCaMP3 imaged zG within their native rosette structure. Here demonstrate rosette, angiotensin II evokes periodic Ca v 3-dependent calcium events form bursts are stereotypic form. Our data reveal critical role regulating burst occurrence, multifunctional activity-prolongation coordination. Combined our define as fundamental unit layer activity evoked by highlight novel facilitator cell communication.