Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state

• DOI: 10.1038/s41467-020-17136-1
• Publication Date: 2020-07-06T10:03:04Z
• Authors: Takeshi Kawabe; Jaeu Yi; Akihisa Kawajiri; Kerry Hilligan; Difeng Fang; Naoto Ishii; Hidehiro Yamane; Jinfang Zhu; Dragana Jankovic; Kwang Soon Kim; Giorgio Trinchieri; Alan Sher
• Keywords: Homeostasis

Abstract CD4 + T lymphocytes consist of naïve, antigen-specific memory, and memory-phenotype (MP) cell compartments at homeostasis. We recently showed that MP cells exert innate-like effector function during host defense, but whether are functionally heterogeneous and, if so, what signals specify the differentiation subpopulations under homeostatic conditions is still unclear. Here we characterize as consisting T-bet high , low − subsets, with innate, Th1-like activity exclusively associated cells. further show latter population depends on IL-12 produced by CD8α type 1 dendritic (DC1) for its differentiation. Finally, our data demonstrate this tonic production requires TLR-MyD88 signaling independent foreign agonists, enhanced CD40-CD40L interactions between DC1 lymphocytes. propose optimal homeostasis driven self-recognition both DC Tcell levels.