Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression

• DOI: 10.1038/s41467-020-18412-w
• Publication Date: 2020-09-16T10:04:39Z
• Authors: Leonidas S. Lundell; Evelyn B. Parr; Brooke L. Devlin; Lars R. Ingerslev; Ali Altıntaş; Shogo Sato; Paolo Sassone-Corsi; Romain Barrès; Juleen R. Zierath; John A. Hawley
• Keywords: [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism; Adult; Male; 2. Zero hunger; Cross-Over Studies; Science; Q; Gene Expression; [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology; Fasting; [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism; Overweight; [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology; Lipid Metabolism; Lipids; Article; Circadian Rhythm; [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition; Circadian Clocks; Humans; Amino Acids; Muscle, Skeletal; [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition

Time-restricted feeding (TRF) improves metabolism independent of dietary macronutrient composition or energy restriction. To elucidate mechanisms underpinning the effects short-term TRF, we investigated skeletal muscle and serum metabolic transcriptomic profiles from 11 men with overweight/obesity after TRF (8 h day-1) extended (EXF, 15 in a randomised cross-over design (trial registration: ACTRN12617000165381). Here show that core clock gene expression was similar both interventions. increases amplitude oscillating transcripts, but not metabolites. In muscle, induces rhythmicity several amino acid transporter genes serum, lipids are largest class periodic metabolites, while majority phase-shifted metabolites related. conclusion, overweight affects regulates controlling transport, without perturbing expression.