Social attraction in Drosophila is regulated by the mushroom body and serotonergic system

• DOI: 10.1038/s41467-020-19102-3
• Publication Date: 2020-10-22T10:02:51Z
• Authors: Yuanjie Sun; Rong Qiu; Xiaonan Li; Yaxin Cheng; Shan Gao; Fanchen Kong; Li Liu; Yan Zhu
• Keywords: Sociality; Mushroom bodies; Social Behavior

Sociality is among the most important motivators of human behaviour. However, neural mechanisms determining levels sociality are largely unknown, primarily due to a lack suitable animal models. Here, we report presence surprising degree general in Drosophila. A newly-developed paradigm study social approach behaviour flies reveal that cues perceive through both vision and olfaction converged central brain region, γ lobe mushroom body, which exhibite activation response experience. The activity these neurons control motivational drive for interaction. At molecular level, serotonergic system critical affinity. These results demonstrate Drosophila highly sociable, providing model elucidating underlying motivation sociality.