Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury

• DOI: 10.1038/s41467-020-19453-x
• Publication Date: 2020-11-17T11:02:56Z
• Authors: Elisa M. Floriddia; Tânia Lourenço; Shupei Zhang; David van Bruggen; Markus M. Hilscher; Petra Kukanja; João P. Gonçalves...; Müge Altınkök; Chika Yokota; Enric Llorens-Bob...; Sara B. Mulinyawe; Mário Grãos; Lu O. Sun; Jonas Frisén; Mats Nilsson; Gonçalo Castelo-B...
• Keywords: Lineage (genetic); Cell type

Abstract Mature oligodendrocytes (MOLs) show transcriptional heterogeneity, the functional consequences of which are unclear. MOL heterogeneity might correlate with local environment or their interactions different neuron types. Here, we that distinct populations have spatial preference in mammalian central nervous system (CNS). We found type 2 (MOL2) is enriched spinal cord when compared to brain, while types 5 and 6 (MOL5/6) increase contribution OL lineage age all analyzed regions. MOL2 MOL5/6 also regions where motor sensory tracts run. progenitor cells (OPCs) not specified into during development, excluding a major OPC intrinsic mechanisms determining heterogeneity. In disease, present susceptibility chronic phase following traumatic injury. Our results demonstrate responses disease.