Predicting the public health impact of a malaria transmission-blocking vaccine

• DOI: 10.1038/s41467-021-21775-3
• Publication Date: 2021-03-08T11:03:05Z
• Authors: Joseph D. Challenger; Daniela Olivera Mesa; Dari F. Da; R. Serge Yerbanga; Thierry Lefèvre; Anna Cohuet; Thomas S. Churcher
• Keywords: Public Health Interventions; Blocking (statistics); Vaccine efficacy

Abstract Transmission-blocking vaccines that interrupt malaria transmission from humans to mosquitoes are being tested in early clinical trials. The activity of such a vaccine is commonly evaluated using membrane-feeding assays. Understanding the field efficacy requires knowledge how heavily infected wild, naturally blood-fed are, as this indicates difficult it will be block transmission. Here we use data on collected Burkina Faso translate laboratory-estimated into an estimated field. A dynamics model then utilised predict transmission-blocking vaccine’s public health impact alongside existing interventions. suggests school-aged children attractive population target for vaccination. Benefits vaccination distributed across population, averting greatest number cases younger children. Utilising interventions could have substantial against malaria.