Etiological, epidemiological, and clinical features of acute diarrhea in China

• DOI: 10.1038/s41467-021-22551-z
• Publication Date: 2021-04-29T10:05:37Z
• Authors: Li-Ping Wang; Shi-Xia Zhou; Xin Wang; Qing-Bin Lu; Lu-Sha Shi; Xiang Ren; Hai-Yang Zhang; Yi-Fei Wang; Sheng-Hong Lin; Cui-Hong Zhang; Meng-Jie Geng; Xiao-Ai Zhang; Jun Li; Shi-Wen Zhao; Zhi-Gang Yi; Xiao Chen; Zuo-Sen Yang; Lei Meng; Xin-Hua Wang; Ying-Le Liu; Ai-Li Cui; Sheng-Jie Lai; Meng-Yang Liu; Yu-Liang Zhu; Wen-Bo Xu; Yu Chen; Jian-Guo Wu; Zheng-Hong Yuan; Meng-Feng Li; Liu-Yu Huang; Zhong-Jie Li; Wei Liu; Li-Qun Fang; Huai-Qi Jing; Simon I. Hay; George F. Gao; Wei-Zhong Yang; ; Wei-Zhong Yang; George F. Gao; Zhong-Jie Li; Li-Ping Wang; Xiang Ren; Yi-Fei Wang; Sheng-Hong Lin; Cui-Hong Zhang; Meng-Jie Geng; Xin Wang; Huai-Qi Jing; Wen-Bo Xu; Ai-Li Cui; Yu-Juan Shen; Yan-Yan Jiang; Qiao Sun; Li-Peng Hao; Chu-Chu Ye; Wei Liu; Xiao-Ai Zhang; Liu-Yu Huang; Yong Wang; Wen-Yi Zhang; Ying-Le Liu; Jian-Guo Wu; Qi Zhang; Wei-Yong Liu; Zi-Yong Sun; Fa-Xian Zhan; Ying Xiong; Lei Meng; De-Shan Yu; Chun-Xiang Wang; Sheng-Cang Zhao; Wen-Rui Wang; Xia Lei; Juan-Sheng Li; Yu-Hong Wang; Yan Zhang; Jun-Peng Yang; Yan-Bo Wang; Fu-Cai Quan; Zhi-Jun Xiong; Li-Ping Liang; Quan-E Chang; Yun Wang; Ping Wang; Zuo-Sen Yang; Ling-Ling Mao; Jia-Meng Li; Li-Kun Lv; Jun Xu; Chang Shu; Xiao Chen; Yu Chen; Yan-Jun Zhang; Lun-Biao Cui; Kui-Cheng Zheng; Xing-Guo Zhang; Xi Zhang; Li-Hong Tu; Zhi-Gang Yi; Wei Wang; Shi-Wen Zhao; Xiao-Fang Zhou; Xiao-Fang Pei; Tian-Li Zheng; Xiao-Ni Zhong; Qin Li; Hua Ling; Ding-Ming Wang; Shi-Jun Li; Shu-Sen He; Meng-Feng Li; Jun Li; Xun Zhu; Chang-Wen Ke; Hong Xiao; Biao Di; Ying Zhang; Hong-Wei Zhou; Nan Yu; Hong-Jian Li; Fang Yang; Fu-Xiang Wang; Jun Wang
• Keywords: Astrovirus; Etiology

Abstract National-based prospective surveillance of all-age patients with acute diarrhea was conducted in China between 2009‒2018. Here we report the etiological, epidemiological, and clinical features 152,792 eligible enrolled this analysis. Rotavirus A norovirus are two leading viral pathogens detected patients, followed by adenovirus astrovirus. Diarrheagenic Escherichia coli nontyphoidal Salmonella bacterial pathogens, Shigella Vibrio parahaemolyticus . Patients aged <5 years had higher overall positive rate while were more common 18‒45 years. joinpoint analysis revealed age-specific positivity how varied for individual pathogens. Our findings fill crucial gaps distributions enteropathogens change across diarrhea. This allows enhanced identification predominant diarrheal pathogen candidates diagnosis practice targeted application prevention control measures.