Surfactant-guided spatial assembly of nano-architectures for molecular profiling of extracellular vesicles

• DOI: 10.1038/s41467-021-23759-9
• Publication Date: 2021-06-30T10:03:04Z
• Authors: Zhigang Wang; Haitao Zhao; Yan Zhang; Auginia Natalia; Chin-Ann J. Ong; Melissa C. C. Teo; Jimmy B. Y. So; Huilin Shao
• Keywords: Nanomaterials

Abstract The controlled assembly of nanomaterials into desired architectures presents many opportunities; however, current preparations lack spatial precision and versatility in developing complex nano-architectures. Inspired by the amphiphilic nature surfactants, we develop a facile approach to guide nanomaterial integration – organization distribution metal-organic frameworks (MOFs). Named surfactant tunable architecture (STAR), technology leverages varied interactions surfactants with nanoparticles MOF constituents, respectively, direct nanoparticle arrangement while molding growing framework. By matching, achieves not only precise diverse different structures, but also fast aqueous synthesis, solution on solid substrates. Employing approach, dual-probe STAR that comprises peripheral working probes central reference achieve differential responsiveness biomarkers. When applied for profiling clinical ascites, reveals glycosylation signatures extracellular vesicles differentiates cancer patient prognosis.