Miniature neurotransmission is required to maintain Drosophila synaptic structures during ageing

Male Motor Neurons 0301 basic medicine Aging 0303 health sciences Time Factors Science Muscles Q Presynaptic Terminals Evoked Potentials, Motor Synaptic Transmission Article Animals, Genetically Modified Microscopy, Electron 03 medical and health sciences Drosophila melanogaster Models, Animal Animals Drosophila Proteins
DOI: 10.1038/s41467-021-24490-1 Publication Date: 2021-07-20T10:26:57Z
ABSTRACT
Abstract The decline of neuronal synapses is an established feature ageing accompanied by the diminishment function, and in motor system at least, a reduction behavioural capacity. Here, we have investigated Drosophila neuron synaptic terminals during ageing. We observed cumulative fragmentation presynaptic structures both evoked miniature neurotransmission occurring tandem with reduced ability. Through discrete manipulation each modality, find that but not required to maintain architecture increasing events can preserve prolong ability Our results establish neurotransmission, formerly viewed as epiphenomenon, necessary for long-term stability connections.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (80)
CITATIONS (31)