Miniature neurotransmission is required to maintain Drosophila synaptic structures during ageing
Male
Motor Neurons
0301 basic medicine
Aging
0303 health sciences
Time Factors
Science
Muscles
Q
Presynaptic Terminals
Evoked Potentials, Motor
Synaptic Transmission
Article
Animals, Genetically Modified
Microscopy, Electron
03 medical and health sciences
Drosophila melanogaster
Models, Animal
Animals
Drosophila Proteins
DOI:
10.1038/s41467-021-24490-1
Publication Date:
2021-07-20T10:26:57Z
AUTHORS (9)
ABSTRACT
Abstract The decline of neuronal synapses is an established feature ageing accompanied by the diminishment function, and in motor system at least, a reduction behavioural capacity. Here, we have investigated Drosophila neuron synaptic terminals during ageing. We observed cumulative fragmentation presynaptic structures both evoked miniature neurotransmission occurring tandem with reduced ability. Through discrete manipulation each modality, find that but not required to maintain architecture increasing events can preserve prolong ability Our results establish neurotransmission, formerly viewed as epiphenomenon, necessary for long-term stability connections.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (80)
CITATIONS (31)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....