Miniature neurotransmission is required to maintain Drosophila synaptic structures during ageing

• DOI: 10.1038/s41467-021-24490-1
• Publication Date: 2021-07-20T10:26:57Z
• Authors: Soumya Banerjee; Samuel Vernon; Wei Jiao; Ben Jiwon Choi; Evelyne Ruchti; Jamshid Asadzadeh; Olivier Burri; R. Steven Stowers; Brian D. McCabe
• Keywords: Male; Aging; Time Factors; Science; Presynaptic Terminals; release; Synaptic Transmission; Article; Animals, Genetically Modified; glutamate-receptor; 03 medical and health sciences; neuromuscular-junctions; morphology; excitability; Animals; Drosophila Proteins; genetic-analysis; Motor Neurons; 0303 health sciences; Muscles; age-related-changes; Q; transmission; Evoked Potentials, Motor; Microscopy, Electron; Drosophila melanogaster; Models, Animal; complexin; synapses

Abstract The decline of neuronal synapses is an established feature ageing accompanied by the diminishment function, and in motor system at least, a reduction behavioural capacity. Here, we have investigated Drosophila neuron synaptic terminals during ageing. We observed cumulative fragmentation presynaptic structures both evoked miniature neurotransmission occurring tandem with reduced ability. Through discrete manipulation each modality, find that but not required to maintain architecture increasing events can preserve prolong ability Our results establish neurotransmission, formerly viewed as epiphenomenon, necessary for long-term stability connections.