Neural signatures of hyperdirect pathway activity in Parkinson’s disease

• DOI: 10.1038/s41467-021-25366-0
• Publication Date: 2021-08-31T10:02:54Z
• Authors: Ashwini Oswal; Chunyan Cao; Chien-Hung Yeh; Wolf-Julian Neumann; James Gratwicke; Harith Akram; Andreas Horn; Dianyou Li; Shikun Zhan; Chao Zhang; Qiang Wang; Ludvic Zrinzo; Tom Foltynie; Patricia Limousin; Rafal Bogacz; Bomin Sun; Masud Husain; Peter Brown; Vladimir Litvak
• Keywords: Subthalamic Nucleus; Magnetoencephalography; Beta Rhythm; BETA (programming language); Local field potential

Abstract Parkinson’s disease (PD) is characterised by the emergence of beta frequency oscillatory synchronisation across cortico-basal-ganglia circuit. The relationship between anatomy this circuit and within it remains unclear. We address combining recordings from human subthalamic nucleus (STN) internal globus pallidus (GPi) with magnetoencephalography, tractography computational modelling. Coherence supplementary motor area STN high (21–30 Hz) but not low (13-21 range correlated ‘hyperdirect pathway’ fibre densities these structures. Furthermore, activity drove selectively at frequencies suggesting that propagate cortex to basal ganglia via hyperdirect pathway. Computational modelling revealed exaggerated pathway can provoke generation widespread pathological synchrony lower frequencies. These findings suggest a spectral signature pathophysiological role for in PD.