Functional and molecular characterization of a non-human primate model of autism spectrum disorder shows similarity with the human disease

• DOI: 10.1038/s41467-021-25487-6
• Publication Date: 2021-09-15T10:03:49Z
• Authors: Satoshi Watanabe; Tohru Kurotani; Tomofumi Oga; Jun Noguchi; Risa Isoda; Akiko Nakagami; Kazuhisa Sakai; Keiko Nakagaki; Kayo Sumida; Kohei Hoshino; Koichi Saito; Izuru Miyawaki; Masayuki Sekiguchi; Keiji Wada; Takafumi Minamimoto; Noritaka Ichinohe
• Keywords: Neurons; 0301 basic medicine; Neuronal Plasticity; Patch-Clamp Techniques; Autism Spectrum Disorder; Science; Dendritic Spines; Gene Expression Profiling; Valproic Acid; Q; Prefrontal Cortex; Callithrix; Synaptic Transmission; Article; Electric Stimulation; 3. Good health; Disease Models, Animal; 03 medical and health sciences; Animals; Humans; Evoked Potentials; Oligonucleotide Array Sequence Analysis

AbstractAutism spectrum disorder (ASD) is a multifactorial disorder with characteristic synaptic and gene expression changes. Early intervention during childhood is thought to benefit prognosis. Here, we examined the changes in cortical synaptogenesis, synaptic function, and gene expression from birth to the juvenile stage in a marmoset model of ASD induced by valproic acid (VPA) treatment. Early postnatally, synaptogenesis was reduced in this model, while juvenile-age VPA-treated marmosets showed increased synaptogenesis, similar to observations in human tissue. During infancy, synaptic plasticity transiently increased and was associated with altered vocalization. Synaptogenesis-related genes were downregulated early postnatally. At three months of age, the differentially expressed genes were associated with circuit remodeling, similar to the expression changes observed in humans. In summary, we provide a functional and molecular characterization of a non-human primate model of ASD, highlighting its similarity to features observed in human ASD.