Epigenetic aging of the demographically non-aging naked mole-rat

• DOI: 10.1038/s41467-022-27959-9
• Publication Date: 2022-01-17T11:02:52Z
• Authors: Csaba Kerepesi; Margarita V. Meer; Julia Ablaeva; Vince G. Amoroso; Sang-Goo Lee; Bohan Zhang; Maxim V. Gerashch...; Alexandre Trapp; Sun Hee Yim; Ake T. Lu; Morgan E. Levine; Andrei Seluanov; Steve Horvath; Thomas J. Park; Vera Gorbunova; Vadim N. Gladyshev
• Keywords: CpG site; Bisulfite sequencing; Bisulfite

Abstract The naked mole-rat (NMR) is an exceptionally long-lived rodent that shows no increase of mortality with age, defining it as a demographically non-aging mammal. Here, we perform bisulfite sequencing the blood > 100 NMRs, assessing 3 million common CpG sites. Unsupervised clustering based on sites whose methylation correlates age reveals age-related methylome remodeling, and also observe information loss, suggesting NMRs age. We develop epigenetic aging clock accurately predicts NMR show these animals much slower than mice faster humans, consistent their known maximum lifespans. Interestingly, patterns changes in Tert Prpf19 differ between mice, but there are conserved two species. Together, data indicate like other mammals, epigenetically even absence demographic this