Rhodium hydride enabled enantioselective intermolecular C–H silylation to access acyclic stereogenic Si–H

• DOI: 10.1038/s41467-022-28439-w
• Publication Date: 2022-02-14T11:12:29Z
• Authors: Kun An; Wenpeng Ma; Li-Chuan Liu; Tao He; Guiyu Guan; Qing-Wei Zhang; Wei He
• Keywords: Stereocenter; Tetrahydrofuran

The tremendous success of stereogenic carbon compounds has never ceased to inspire researchers explore the potentials silicon compounds. Intermolecular C-H silylation thus represents most versatile and straightforward strategy construct C-Si bonds, however, its enantioselective variant been scarcely reported date. Herein we report a protocol that allows for intermolecular bond silylation, leading construction wide array acyclic Si-H under simple mild reaction conditions. Key is (1) substrate design prevents self-reaction prochiral silane (2) employment more reactive rhodium hydride ([Rh]-H) catalyst as opposed commonly used chloride ([Rh]-Cl) catalyst. This work unveils opportunities in converting arenes into value-added