Gut microbiota and fermentation-derived branched chain hydroxy acids mediate health benefits of yogurt consumption in obese mice

• DOI: 10.1038/s41467-022-29005-0
• Publication Date: 2022-03-15T11:03:49Z
• Authors: Noëmie Daniel; Renato Tadeu Nachbar; Thi Thu Trang Tran; Adia Ouellette; Thibault Vincent ...; Aurélie Cotillard; Laurent Quinquis; Andréanne Gagné; Philippe St-Pierre; Jocelyn Trottier; Bruno Marcotte; Marion Poirel; Mathilde Saccareau; Marie-Julie Dubois; Philippe Joubert; Olivier Barbier; Hana Koutnikova; André Marette
• Keywords: Metabolome; Steatosis

Abstract Meta-analyses suggest that yogurt consumption reduces type 2 diabetes incidence in humans, but the molecular basis of these observations remains unknown. Here we show dietary intake preserves whole-body glucose homeostasis and prevents hepatic insulin resistance liver steatosis a mouse model obesity-linked diabetes. Fecal microbiota transplantation studies reveal effects are partly linked to gut microbiota. We further impacts metabolome, notably maintaining levels branched chain hydroxy acids (BCHA) which correlate with improved metabolic parameters. These metabolites generated upon milk fermentation concentrated yogurt. Remarkably, diet-induced obesity plasma tissue BCHA levels, this is prevented by intake. improve action on metabolism muscle cells, identifying as cell-autonomous regulators potential mediators yogurt’s health effects.