The gut microbiota-bile acid axis links the positive association between chronic insomnia and cardiometabolic diseases

• DOI: 10.1038/s41467-022-30712-x
• Publication Date: 2022-05-30T10:04:34Z
• Authors: Zengliang Jiang; Lai-bao Zhuo; Yan He; Yuanqing Fu; Luqi Shen; Fengzhe Xu; Wanglong Gou; Zelei Miao; Menglei Shuai; Yuhui Liang; Congmei Xiao; Xinxiu Liang; Yunyi Tian; Jiali Wang; Jun Tang; Kui Deng; Hongwei Zhou; Yu-ming Chen; Ju-Sheng Zheng
• Keywords: Bile Acids and Salts; 0301 basic medicine; 03 medical and health sciences; Cross-Sectional Studies; Cardiovascular Diseases; Science; Sleep Initiation and Maintenance Disorders; Q; Humans; Cholic Acid; Article; Gastrointestinal Microbiome

Abstract Evidence from human cohorts indicates that chronic insomnia is associated with higher risk of cardiometabolic diseases (CMD), yet whether gut microbiota plays a role unclear. Here, in longitudinal cohort ( n = 1809), we find the microbiota-bile acid axis may link positive association between and CMD. Ruminococcaceae UCG-002 UCG-003 are main genera mediating These results also observed an independent cross-sectional 6122). The inverse associations those microbial biomarkers CMD mediated by certain bile acids (isolithocholic acid, muro cholic nor acid). Habitual tea consumption prospectively identified opposite direction compared insomnia. Our work suggests be potential intervention target for reducing impact on health.