Augmented ultrasonography with implanted CMOS electronic motes

• DOI: 10.1038/s41467-022-31166-x
• Publication Date: 2022-06-20T11:09:08Z
• Authors: Yihan Zhang; Prashant Muthuraman; Victoria Andino-P...; Ilke Uguz; Jeffrey Elloian; Kenneth L. Shepard
• Keywords: Duty cycle; Backscatter (email)

Abstract Modern clinical practice benefits significantly from imaging technologies and much effort is directed toward making this more informative through the addition of contrast agents or reporters. Here, we report design a battery-less integrated circuit mote acting as an electronic reporter during medical ultrasound imaging. When implanted within field-of-view brightness-mode (B-mode) imager, transmits information its location backscattered acoustic energy which captured image itself. We prototype characterize operation such motes in vitro vivo. Performing with static power consumption less than 57 pW, operate at duty cycles for receiving low 50 ppm. Motes same have demonstrated signal-to-noise ratios 19.1 dB depths up to 40 mm lossy phantom. Physiological acquired motes, beyond what measurable endogenous backscatter biogeographically located image, has potential provide augmented ultrasonography.