Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen

• DOI: 10.1038/s41467-022-32811-1
• Publication Date: 2022-09-10T16:02:41Z
• Authors: Andrew Poole; Vijaykumar Karuppiah; Annabelle Hartt; Jaafar N. Haidar; Sylvie Moureau; Tomasz Dobrzycki; Conor Hayes; Christopher Rowley; Jorge Dias; Stephen Harper; Keir Barnbrook; Miriam Hock; Charlotte Coles; Wei Yang; Milos Aleksic; Aimee Bence Lin; Ross Robinson; Joe D. Dukes; Nathaniel Liddy; Marc Van der Kamp; Gregory D. Plowman; Annelise Vuidepot; David K. Cole; Andrew D. Whale; Chandramouli Chil...
• Keywords: Proto-Oncogene Proteins p21(ras); 0303 health sciences; 03 medical and health sciences; Lung Neoplasms; Science; Q; Receptors, Antigen, T-Cell; 610; 500; Humans; Article; 3. Good health

Neoantigens derived from somatic mutations are specific to cancer cells and ideal targets for immunotherapy. KRAS is the most frequently mutated oncogene drives pathogenesis of several cancers. Here we show identification development an affinity-enhanced T cell receptor (TCR) that recognizes a peptide common mutant,