Bidirectional lysosome transport: a balancing act between ARL8 effectors

• DOI: 10.1038/s41467-022-32965-y
• Publication Date: 2022-09-08T12:10:33Z
• Authors: Agnieszka A. Kend...; Jenna R. Christensen
• Keywords: Kinesin; Organelle; Axoplasmic transport

Most organelles move bidirectionally on microtubule tracks, yet how this opposing movement is regulated by kinesin and dynein remains unclear. Recent work found that ARL8, a known anterograde adaptor linking the lysosome to kinesin, also links lysosomes retrograde motor dynein, providing key insight into bidirectional organelle in cells.